She made her acting debut during the summer of 2010 in the cinepanettone Natale in Sudafrica, directed by Neri Parenti and released on 17 December of that year. That fall Rodríguez appeared in Se sei così, ti dico sì (directed by Eugenio Cappuccio and released on 15 April 2011) and the episode "Il campo del vasaio" of the Rai 1 television series Il commissario Montalbano, which premiered on 14 March 2011. Rodríguez guest starred in several episodes of the second season of Così fan tutte, an Italia 1 sitcom directed by Gianluca Fumagalli, in 2011–2012. She dubbed her voice in the animated film Gladiatori di Roma, directed by Iginio Straffi and released on 18 October 2012. During the summer of 2014 Rodríguez appeared in Non c'è 2 senza te, directed by Massimo Cappelli and released on 5 February 2015. In August 2015 Lux Vide and RAI Fiction announced that she would guest-star in "La colpa [it]", a tenth-season episode of the Rai 1 TV series Don Matteo which premiered on 7 January 2016.