In the early 1970s Calà co-founded together with Umberto Smaila, Franco Oppini and Ninì Salerno a cabaret-ensemble, "i gatti di Vicolo Miracoli". In early 80s, after two films with the group, he started a solo career as leading actor in numerous comedy films, obtaining a great popularity in Italy. In 1993 he starred in the dramatic movie Diary of a Maniac, directed by Marco Ferreri and which was entered into the 43rd Berlin International Film Festival, where Calà won the award for best actor for the italian film criticism. He debuted as director in 1994 with Chicken Park, a low-budget parody of Jurassic Park. His most famous films are: I fichissimi (1981), Time for Loving (1983), Vacanze di Natale (1983), Vacanze in America (1984) and Yuppies - The italian young people (1986) directed by Carlo Vanzina; I'm Going to Live by Myself (1982) and A Boy and a Girl (1984) directed by Marco Risi; Yuppies 2 (1986) directed by Enrico Oldoini; Bomber (1982) directed by Michele Lupo; At the sports bar (1983) directed by Francesco Massaro; Rimini Rimini (1987) directed by Sergio Corbucci; Professione vacanze (1987) directed by Vittorio De Sisti; Italian brothers (1989) directed by Neri Parenti; Abbronzatissimi (1991) and Abbronzatissimi 2 - A year again (1993) directed by Bruno Gaburro; Diary of a maniac (1993) directed by Marco Ferreri; Vita smeralda (2006) and Torno a vivere da solo (2008) directed by himself.